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Title   진행성 비소세포 페암에서 Vinorelbine , Ifosfamide , Cisplatin 3 제 복합화학요법의 효과 ( Efficacy of Combination Chemotherapy with Vinorelbine , Ifosfamide , and Cisplatin in Patients with Advanced Non - Small Cell Lung Cancer )
Publicationinfo   2000 Jan; 032(03): 612-619.
Key_word   Non - small cell lung cancer , Vinorelbine , Ifosfamide , Cisplatin , Chemotherapy
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Abstract   Purpose: To evaluate the efficacy and toxicity of combination chemotherapy with vinorelbine, ifosfamide, and cisplatin in patients with advanced non-small cell lung cancer. Materials and Methods: Patients with unresectable, pathologically proven non-small cell lung cancer who had no prior chemotherapy were eligible. Patients received vinorelbine (25 mg/m, iv., Dl 8c 8), ifosfamide (1.5 g/m, iv., Dl-3 with mesna), and cisplatin (60 mg/m, iv., Dl). The treatment was repeated every 3 weeks. Results: Between October, 1997 and June, 1999, 26 patients were enrolled. Median age was 61. 1 patient had stage IIIA, 13 had stage IIIB, and 12 had stage IV. Patients with adenocarcinoma were 15, squamous cell carcinoma were 11. Of 22 evaluable patients, objective responses were observed in 9 patients (response rate: 40.9%, CR: 1 (4.5%), PR 8 (36.4%)). Median duration of response was 48 weeks. Median overall survival was 52 weeks. Grade 3-4 leukopenia was observed in 10.2% of the 88 courses. There was 1 death related to febrile neutropenia. Non-hematologic toxicities were mild. Conclusion: We concluded that combination chemotherapy with vinorelbine, ifosfamide, and cisplatin was effective and tolerable in patients with advanced non-small cell lung cancer, and phase III randomized trial is needed to compare this regimen to other cisplatin-based regimens.
저 자   장흥문(Heung Moon Chang),이정애(Jung Ae Lee),안진석(Jin Seok Ahn),우인숙(In Sook Woo),박영이(Young Iee Park),손지웅(Jee Woong Son),이승준(Seung Joon Lee),정기석(Ki Suck Jung),박영석(Young Suk Park)